HI TOPK 032

Name: HI TOPK 032
Brand: Tocris Bioscience
SKU: 4555

Cat. No. 4555 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4555 has been discontinued.

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说明： Selective T-LAK-cell-originated protein kinase (TOPK) inhibitor

化学名： N-(12-Cyanoindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for HI TOPK 032

HI TOPK 032 is a T-LAK-cell-originated protein kinase (TOPK) inhibitor; exhibits selectivity for TOPK over other MAPKK family members including ERK1, JNK1 and p38. Blocks proliferation of HCT116 colon cancer cells; suppresses tumor growth in a colon cancer xenograft model. Also inhibits Chk1 (IC₅₀ = 9.6 μM).

技术数据 for HI TOPK 032

分子量	369.4
公式	C₂₀H₁₁N₅OS
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	487020-03-1
PubChem ID	1936439
InChI Key	BCSBXWKRZUPFHW-UHFFFAOYSA-N
Smiles	O=C(C5=CC=CS5)NC4=CC3=C(C#N)C2=NC1=CC=CC=C1N=C2N3C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for HI TOPK 032

分析证书/产品说明书

化学品安全技术说明书

参考文献 for HI TOPK 032

参考文献是支持产品生物活性的出版物。

Li et al (2011) Discovery of novel checkpoint kinase 1 inhibitors by virtual screening based on multiple crystal structures. J.Chem.Inf.Model. 51 2904 PMID: 21955044

Kim et al (2012) Novel TOPK inhibitor HI-TOPK-032 effectively suppresses colon cancer growth. Cancer Res. 72 3060 PMID: 22523035

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关键词: HI TOPK 032, HI TOPK 032 supplier, HITOPK032, TOPK, T-LAK-cell-originated, protein, kinase, MAPKK, inhibitors, inhibits, selective, antitumor, colon, cancer, cells, antiproliferatives, Other, MAPK, 4555, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.