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说明： Partial positive allosteric modulator at the benzodiazepine site
别名： Dinatin
化学名： 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
纯度： ≥98% (HPLC)
生物活性 for Hispidulin
Hispidulin is a partial positive allosteric modulator at the benzodiazepine receptor (IC50 = 1.3 μM for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α1-, α2-, α3-, α5- or α6-β2 γ2S GABAA receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
技术数据 for Hispidulin
| 分子量 | 300.27 |
| 公式 | C16H12O6 |
| 储存 | Desiccate at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1447-88-7 |
| PubChem ID | 5281628 |
| InChI Key | IHFBPDAQLQOCBX-UHFFFAOYSA-N |
| Smiles | OC1=CC2=C(C(C=C(C3=CC=C(O)C=C3)O2)=O)C(O)=C1OC |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Hispidulin
参考文献 for Hispidulin
参考文献是支持产品生物活性的出版物。
Bourdillat et al (1988) Hispidulin, a natural flavone, inhibits human platelet aggregation by increasing cAMP levels. Eur.J.Pharmacol. 147 1 PMID: 2836213
Kavvadias et al (2003) Constituents of sage (Salvia officinalis) with in vitro affinity to human brain benzodiazepine receptor. Planta Med. 69 113 PMID: 12624814
Kavvadias et al (2004) The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects. Br.J.Pharmacol. 142 811 PMID: 15231642
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关键词: Hispidulin, Hispidulin supplier, Partial, positive, allosteric, modulators, benzodiazepine, receptor, GABAA, Receptors, GABAC, PAM, Dinatin, 2174, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.