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Submit ReviewHTMT dimaleate
说明： H1/ H2 agonist
别名： Histamine trifluoromethyl toluidide
化学名： 6-[2-(4-Imidazolyl)ethylamino]-N-(4-trifluoromethylphenyl)heptanecarboxamide dimaleate
纯度： ≥99% (HPLC)
生物活性 for HTMT dimaleate
HTMT dimaleate is a H1 and H2 receptor agonist. 4x104 times more active than histamine in H2-mediated effects in natural suppressor cells. Increases intracellular Ca2+ and IP3 in lymphocytes through a binding site other than H1, H2 or H3.
技术数据 for HTMT dimaleate
| 分子量 | 614.57 |
| 公式 | C19H25F3N4O.2C4H4O4 |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 195867-54-0 |
| PubChem ID | 45073433 |
| InChI Key | ODAOZWTYNWZSBY-SPIKMXEPSA-N |
| Smiles | [H]OC(=O)\C=C/C(=O)O[H].[H]OC(=O)\C=C/C(=O)O[H].CC(CCCCC(=O)NC1=CC=C(C=C1)C(F)(F)F)NCCC1=CNC=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for HTMT dimaleate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 61.46 | 100 |
制备储备液 for HTMT dimaleate
以下数据基于产品分子量 614.57。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.63 mL | 8.14 mL | 16.27 mL |
| 5 mM | 0.33 mL | 1.63 mL | 3.25 mL |
| 10 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 50 mM | 0.03 mL | 0.16 mL | 0.33 mL |
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产品说明书 for HTMT dimaleate
参考文献 for HTMT dimaleate
参考文献是支持产品生物活性的出版物。
Khan et al (1986) The effects of derivatives of histamine on natural suppressor cells. J.Immunol. 137 308 PMID: 3011908
Khan et al (1987) Congener derivatives and conjugates of histamine: synthesis and tissue receptor selectivity of the derivatives. J.Med.Chem. 30 2115 PMID: 2959777
Shahid et al (2009) Histamine, histamine receptors and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9
If you know of a relevant reference for HTMT dimaleate, please let us know.
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关键词: HTMT dimaleate, HTMT dimaleate supplier, H2, H1, agonists, Receptors, Histamine, histaminergic, trifluoromethyl, toluidide, 0646, Tocris Bioscience
2 篇 HTMT dimaleate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 HTMT dimaleate 的部分引用包括：
Tripathi et al (2011) The Influence of histamine H1-receptor on liver functions in immunized rabbits. EMBO J 18 411 PMID: 23961154
Mishra et al (2011) TRPV1-lineage neurons are required for thermal sensation. Br J Ophthalmol 30 582 PMID: 21139565
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.