Hydroxy Dynasore

Cat. No. 5364 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Dynamin inhibitor; analog of dynasore (Cat. No. 2897)

别名： Dyngo 4a

化学名： 3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5)-trihydroxyphenyl)methylene]hydrazide

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Hydroxy Dynasore

Hydroxy Dynasore is a dynamin inhibitor (IC₅₀ values are 0.38 and 2.6 μM for dynamin 1 and 2 respectively). Inhibits dynamin-mediated endocytosis in multiple cell types and reduces synaptic vesicle endocytosis in vitro. Prevents botulinum A internalization in hippocampal neurons. Also protects against botulinum A-induced muscle paralysis in rats. Analog of Dynasore (Cat. No. 2897).

技术数据 for Hydroxy Dynasore

分子量	338.31
公式	C₁₈H₁₄N₂O₅
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	1256493-34-1
PubChem ID	72193863
InChI Key	ATUDAZGVGGVSOP-XFXZXTDPSA-N
Smiles	OC1=CC2=CC=CC=C2C=C1C(N/N=C/C3=C(O)C=C(O)C(O)=C3)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Hydroxy Dynasore

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	32.23	100

制备储备液 for Hydroxy Dynasore

以下数据基于产品分子量 338.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.56 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.3 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.3 mL	0.59 mL

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产品说明书 for Hydroxy Dynasore

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Hydroxy Dynasore

参考文献是支持产品生物活性的出版物。

Harper et al (2011) Dynamin inhibition blocks botulinum neurotoxin type A endocytosis in neurons and delays botulism. J.Biol.Chem. 286 35966 PMID: 21832053

McCluskey et al (2013) Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic 14 1272 PMID: 24025110

If you know of a relevant reference for Hydroxy Dynasore, please let us know.

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关键词: Hydroxy Dynasore, Hydroxy Dynasore supplier, dynamin, gtpases, dynamin1, dynamin2, endocytosis, botulinum, Dyngo, 4a, Dynamin, 5364, Tocris Bioscience

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