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Submit ReviewICI 174,864
说明： δ selective peptide antagonist
纯度： ≥95% (HPLC)
生物活性 for ICI 174,864
ICI 174,864 is a selective δ opioid antagonist. Exhibits partial agonist in vitro activity at δ receptors at high concentrations.
许可信息
Sold with the permission of AstraZeneca UK Ltd.
技术数据 for ICI 174,864
| 分子量 | 691.87 |
| 公式 | C38H53N5O7 |
| 序列 |
YXXFL (Modifications: Tyr-1 = N,N-diallyl-Tyr, X = Aib) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 89352-67-0 |
| PubChem ID | 44149909 |
| InChI Key | XUWLAGNFLUARAN-CHQNGUEUSA-N |
| Smiles | CC(C)C[C@H](NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)C(C)(C)NC(=O)C(C)(C)NC(=O)[C@H](CC1=CC=C(O)C=C1)N(CC=C)CC=C)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ICI 174,864
| 溶解性 | Soluble to 69.19 mg/ml in DMSO and to 1 mg/ml in water |
产品说明书 for ICI 174,864
参考文献 for ICI 174,864
参考文献是支持产品生物活性的出版物。
Cohen et al (1996) Opioid agonist activity of ICI 174864 and its carboxypeptidase degradation product, LY281217. J.Pharmacol.Exp.Ther. 238 769 PMID: 2875170
Cotton et al (1984) ICI-174,864: a highly selective antagonist for the opioid δ receptor. Eur.J.Pharmacol. 97 331 PMID: 6323195
Cowan et al (1985) Studies in vivo with ICI-174,864 and [D-Pen2,D-Pen5]-enkephalin. Neuropeptides 5 311 PMID: 2987731
Hirning et al (1985) Studies in vitro with ICI-174,864 [D-Pen2,D-Pen5]-enkephalin (DPDPE) and [D-Ala2,NMePhe4,Gly-ol]-enkephalin (DAGO). Neuropeptides 5 383 PMID: 2987739
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关键词: ICI 174,864, ICI 174,864 supplier, δ-opioid, delta-opioid, selective, peptide, antagonists, DOP, Receptors, OP1, ICI174864, AstraZeneca, Delta, Opioid, 0820, Tocris Bioscience
5 篇 ICI 174,864 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ICI 174,864 的部分引用包括：
Leroy et al (2017) Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron 95 1089 PMID: 28823730
Birdsong et al (2019) Synapse-specific opioid modulation of thalamo-cortico-striatal circuits. Elife 8 PMID: 31099753
Neilan et al (1999) Constitutive activity of the delta-opioid receptor expressed in C6 glioma cells: identification of non-peptide delta-inverse agonists. Br J Pharmacol 128 556 PMID: 10516632
Gallego et al (2009) Opioid and progesterone signaling is obligatory for early human embryogenesis. J Neurophysiol 18 737 PMID: 18803462
Markkanen and Petäjä-Repo (2008) N-glycan-mediated quality control in the endoplasmic reticulum is required for the expression of correctly folded delta-opioid receptors at the cell surface. J Biol Chem 283 29086 PMID: 18703511
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