Icilin

Cat. No. 1531 5 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Activates cold receptors. Cooling agent

别名： AG 3-5

化学名： 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one

纯度： ≥98% (HPLC)

引用文献 (5)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Icilin

Icilin is a cooling agent that activates the novel cold receptors TRPM8 (CMR1) and TRPA1 (ANKTM1/TRPN1), members of the TRP ion channel family. Induces currents in CMR1-expressing HEK 293 cells (EC₅₀ = 0.36 μM) more potently than menthol or low temperatures. Produces "wet shakes" in vivo.

技术数据 for Icilin

分子量	311.3
公式	C₁₆H₁₃N₃O₄
储存	Store at RT
纯度	≥98% (HPLC)
CAS Number	36945-98-9
PubChem ID	161930
InChI Key	RCEFMOGVOYEGJN-UHFFFAOYSA-N
Smiles	OC1=C(C=CC=C1)N1CC=C(NC1=O)C1=CC=CC(=C1)[N+]([O-])=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Icilin

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	31.13	100

制备储备液 for Icilin

以下数据基于产品分子量 311.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.06 mL	32.12 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.61 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

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产品说明书 for Icilin

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Icilin

参考文献是支持产品生物活性的出版物。

Behrendt et al (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br.J.Pharmacol. 141 737 PMID: 14757700

McKemy et al (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416 52 PMID: 11882888

Story et al (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112 819 PMID: 12654248

Wei et al (1983) AG-3-5: a chemical producing sensations of cold. J.Pharm.Pharmacol. 35 110 PMID: 6131976

Diver et al (2019) Science.

If you know of a relevant reference for Icilin, please let us know.

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