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Submit ReviewIdazoxan hydrochloride
Discontinued Product
0793 has been discontinued.
View all Adrenergic α<sub>2</sub> Receptors products.
说明： α2 antagonist. Also I2 ligand
别名： RX 781094
化学名： 2-(1,4-Benzodioxan-2-yl)-2-imidazoline hydrochloride
纯度： ≥98%
生物活性 for Idazoxan hydrochloride
Idazoxan hydrochloride is a α2-adrenoceptor antagonist, and I2 ligand, selective over I1 sites (pKi values are 5.90, 7.22, 8.01, 7.43, and 7.7 for I1, I2, α2A, α2B, and α2C receptors respectively).
技术数据 for Idazoxan hydrochloride
| 分子量 | 240.69 |
| 公式 | C11H12N2O2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% |
| CAS Number | 79944-56-2 |
| PubChem ID | 154494 |
| InChI Key | MYUBYOVCLMEAOH-UHFFFAOYSA-N |
| Smiles | Cl.C1CN=C(N1)C1COC2=CC=CC=C2O1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Idazoxan hydrochloride
参考文献 for Idazoxan hydrochloride
参考文献是支持产品生物活性的出版物。
Berdeu et al (1995) Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat. Eur.J.Pharmacol. 275 91 PMID: 7774667
Dabir (1986) Idazoxan: a novel pharmacological tool for the study of α2-adrenoceptors. J.Pharmacol. 17 113 PMID: 2875218
Eglen et al (1998) 'Seeing through a glass darkly': casting light on imidazoline 'I' sites. TiPS 19 381 PMID: 9786027
Michel and Ernsberger (1992) Keeping an eye on the I site: imidazoline-preferring receptors. TIPS 13 369 PMID: 1413085
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关键词: Idazoxan hydrochloride, Idazoxan hydrochloride supplier, α2-adrenoceptor, alpha2-adrenoceptor, a2-adrenoceptor, a2-adrenergic, α2-Adrenergic, alpha2-Adrenergic, antagonists, I2, ligand, Receptors, Imidazoline, RX781094, RX, 781094, Adrenergic, Alpha-2, 0793, Tocris Bioscience
2 篇 Idazoxan hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Idazoxan hydrochloride 的部分引用包括：
Bucher et al (2014) Medullary NE neurons modulate local oxygen concentrations in the bed nucleus of the stria terminalis. J Cereb Blood Flow Metab 34 1128 PMID: 24714037
Sadeghi et al (2015) μ-Opioid receptor activation and noradrenaline transport inhibition by tapen. in rat single locus coeruleus neurons. Development 172 460 PMID: 24372103
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.