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说明： Induces definitive endoderm formation in mouse and human ESCs
化学名： 1-[2-[(2-Carboxyphenyl)methylene]hydrazide]heptanoic acid
纯度： ≥98% (HPLC)
生物活性 for IDE 1
IDE 1 is an induces definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 125 nM). Thought to activate the TGF-β signaling pathway; induces Smad2 phosphorylation and increases levels of Nodal expression.
This compound is mixture of E/Z isomers.
许可信息
Sold for research purpose under license from Harvard University.
技术数据 for IDE 1
| 分子量 | 306.31 |
| 公式 | C15H18N2O5 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1160927-48-9 |
| PubChem ID | 66974738 |
| InChI Key | ABKJCDILEUEJSH-UHFFFAOYSA-N |
| Smiles | OC(=O)CCCCCC(=O)NN=CC1=CC=CC=C1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for IDE 1
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 2eq. NaOH | 30.63 | 100 | |
| DMSO | 30.63 | 100 |
制备储备液 for IDE 1
以下数据基于产品分子量 306.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.26 mL | 16.32 mL | 32.65 mL |
| 5 mM | 0.65 mL | 3.26 mL | 6.53 mL |
| 10 mM | 0.33 mL | 1.63 mL | 3.26 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.65 mL |
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产品说明书 for IDE 1
参考文献 for IDE 1
参考文献是支持产品生物活性的出版物。
Borowiak et al (2009) Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell 4 348 PMID: 19341624
Zaret (2009) Using small molecules to great effect in stem cell differentiation. Cell Stem Cell 4 373 PMID: 19427285
Filby et al (2011) Stimulation of AVNA/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells. Stem Cell Res.Ther. 2 16 PMID: 21463501
If you know of a relevant reference for IDE 1, please let us know.
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关键词: IDE 1, IDE 1 supplier, IDE1, stem, cells, induces, definitive, endoderm, human, mouse, ESCs, tgfb, transforming, growth, factors, beta, b, β, signaling, signalling, nodal, and, iPSC, 4015, Tocris Bioscience
3 篇 IDE 1 的引用文献
引用文献是使用了 Tocris 产品的出版物。 IDE 1 的部分引用包括：
Marjo et al (2018) Differences in definitive endoderm induction approaches using growth factors and small molecules. J Cell Physiol 233 3578-3589 PMID: 29044512
Xu et al (2015) Rapid and high-efficiency generation of mature functional hepatocyte-like cells from adipose-derived stem cells by a three-step protocol. Stem Cell Res 6 193 PMID: 26438426
Kearns et al (2013) Generation of organized anterior foregut epithelia from pluripotent stem cells using small molecules. J Cell Mol Med 11 1003 PMID: 23917481
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.