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说明： Antioxidant and neuroprotective agent
化学名： 2-(10-Hydroxydecyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione
纯度： ≥99% (HPLC)
生物活性 for Idebenone
Idebenone is an antioxidant and neuroprotective agent. Protects mitochondrial membranes against lipid peroxidation and blocks glutamate neurotoxicity in vitro and in vivo. Inhibits apoptosis of astrocytes via increased NGF production.
技术数据 for Idebenone
| 分子量 | 338.44 |
| 公式 | C19H30O5 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 58186-27-9 |
| PubChem ID | 3686 |
| InChI Key | JGPMMRGNQUBGND-UHFFFAOYSA-N |
| Smiles | O=C(C(OC)=C1OC)C(CCCCCCCCCCO)=C(C)C1=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Idebenone
参考文献 for Idebenone
参考文献是支持产品生物活性的出版物。
Zs-Nagy (1990) Chemistry, toxicology, pharmacology and pharmacokinetics of idebenone: a review. Arch.Gerontol.Geriatr. 11 177 PMID: 15374467
Civenni et al (1999) Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. Eur.J.Pharmacol. 370 161 PMID: 10323265
Takuma et al (2000) CV-2619 protects cultured astrocytes against reperfusion injury via nerve growth factor production. Eur.J.Pharmacol. 406 333 PMID: 11040339
关键词: Idebenone, Idebenone supplier, Antioxidant, neuroprotective, agent, Antioxidants, Ferroptosis, 3002, Tocris Bioscience
1 篇 Idebenone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Idebenone 的部分引用包括：
Liu et al (2014) Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxid Redox Signal 21 1571 PMID: 24328731
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