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Submit ReviewIEM 1754 dihydrobromide
说明： Voltage-dependent, open-channel AMPA blocker
化学名： N-(Tricyclo[3.3.1.13,7]dec-1-ylmethyl)-1,5-pentanediamine dihydrobromide
纯度： ≥98% (HPLC)
生物活性 for IEM 1754 dihydrobromide
IEM 1754 dihydrobromide is a voltage-dependent open-channel blocker of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking (Ca2+-permeable) receptors more potently than GluA2-containing receptors. Also potently blocks NMDA receptor channels. Less sensitive than IEM 1460 (Cat. No. 1460) at a holding potential between -40 and -80mV.
技术数据 for IEM 1754 dihydrobromide
| 分子量 | 412.25 |
| 公式 | C16H30N2.2HBr |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 162831-31-4 |
| PubChem ID | 9887867 |
| InChI Key | JMPHTNNJCZDROM-UHFFFAOYSA-N |
| Smiles | NCCCCCNCC1(CC3C2)CC(C3)CC2C1.Br.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for IEM 1754 dihydrobromide
参考文献 for IEM 1754 dihydrobromide
参考文献是支持产品生物活性的出版物。
Magazanik et al (1997) Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives. J.Physiol. 505 655 PMID: 9457643
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232
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关键词: IEM 1754 dihydrobromide, IEM 1754 dihydrobromide supplier, IEM1754, 2HBr, AMPA, receptor, blocker, blocks, AMPAR, voltage-dependent, Receptors, 4199, Tocris Bioscience
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