Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewIEM 1925 dihydrobromide
说明： Voltage- and use-dependent open-channel AMPA blocker
化学名： N-(1-Phenylcyclohexyl)-1,5-pentanediamine dihydrobromide
纯度： ≥95% (HPLC)
生物活性 for IEM 1925 dihydrobromide
IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (KD for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.
技术数据 for IEM 1925 dihydrobromide
| 分子量 | 422.24 |
| 公式 | C17H28N2.2HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 258282-23-4 |
| PubChem ID | 44561101 |
| InChI Key | ZCYUSVRXEKAQSL-UHFFFAOYSA-N |
| Smiles | NCCCCCNC1(C2=CC=CC=C2)CCCCC1.Br.Br |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for IEM 1925 dihydrobromide
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 42.22 | 100 | |
| DMSO | 21.11 | 50 |
制备储备液 for IEM 1925 dihydrobromide
以下数据基于产品分子量 422.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.37 mL | 11.84 mL | 23.68 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
| 10 mM | 0.24 mL | 1.18 mL | 2.37 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.47 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for IEM 1925 dihydrobromide
参考文献 for IEM 1925 dihydrobromide
参考文献是支持产品生物活性的出版物。
Tikhonov et al (2000) Voltage-dependent block of native AMPA receptor channels by dicationic compounds. Br.J.Pharmacol. 129 265 PMID: 10694232
Kopach et al (2016) Inhibition of spinal Ca2+-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects. Front.Cell Neurosci. 10 PMID: 26973464
If you know of a relevant reference for IEM 1925 dihydrobromide, please let us know.
按产品操作查看相关产品
关键词: IEM 1925 dihydrobromide, IEM 1925 dihydrobromide supplier, IEM1925, 2HBr, AMPAR, antagonist, blocks, AMPA, receptor, voltage-dependent, channel, blocker, Receptors, 4198, Tocris Bioscience
2 篇 IEM 1925 dihydrobromide 的引用文献
引用文献是使用了 Tocris 产品的出版物。 IEM 1925 dihydrobromide 的部分引用包括：
Ondrej et al (2021) Gating and modulation of a hetero-octameric AMPA glutamate receptor. Nature 594 454-458 PMID: 34079129
Terunaga et al (2023) Modulatory mechanisms of TARP γ8-selective AMPA receptor therapeutics. Nat Commun 14 1659 PMID: 36966141
您是否知道使用了 Tocris IEM 1925 dihydrobromide 的优秀论文？ 请告知我们.
IEM 1925 dihydrobromide 的评论
目前没有该产品的评论。 Be the first to review IEM 1925 dihydrobromide and earn rewards!
Have you used IEM 1925 dihydrobromide?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.