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iFSP1

Cat. No. 7162 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ferroptosis suppressor protein 1 (FSP1) inhibitor; ferroptosis inducer
化学名： 1-Amino-3-(4-methylphenyl)-pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for iFSP1

iFSP1 is a ferroptosis inducer. Inhibits ferroptosis suppressor protein 1 (FSP1) and induces ferroptosis in GPX4 knockout cells. Sensitizes tumor cells to RSL3 (Cat. No. 6118) -induced ferroptosis.

技术数据 for iFSP1

分子量 323.36
公式 C20H13N5
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 150651-39-1
PubChem ID 699043
InChI Key FNESYDFRCQEEKA-UHFFFAOYSA-N
Smiles CC1=CC=C(C2=C(C#N)C3=NC4=CC=CC=C4N3C(N)=C2C#N)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for iFSP1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 6.47 20

制备储备液 for iFSP1

以下数据基于产品分子量 323.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 15.46 mL 77.31 mL 154.63 mL
1 mM 3.09 mL 15.46 mL 30.93 mL
2 mM 1.55 mL 7.73 mL 15.46 mL
10 mM 0.31 mL 1.55 mL 3.09 mL

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参考文献 for iFSP1

参考文献是支持产品生物活性的出版物。

Bersuker et al (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575 688 PMID: 31634900

If you know of a relevant reference for iFSP1, please let us know.

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关键词: iFSP1, iFSP1 supplier, ferroptosis, suppressor, protein, 1, FSP1, inhibitors, inhibits, apoptosis, inducing, factor, mitochondria-associated, 2, AIFM2, Other, Reductase, Ferroptosis, 7162, Tocris Bioscience

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