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Immepip dihydrobromide

Cat. No. 0932 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Standard H3 agonist. Also H4 agonist
化学名： 4-(1H-Imidazol-4-ylmethyl)piperidine dihydrobromide
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Immepip dihydrobromide

Immepip dihydrobromide is a potent histamine H3 receptor agonist. Also binds to H4 receptors (Ki values are 0.4 and 9 nM at human recombinant H3 and H4 receptors respectively). Equipotent to or slightly more active than (R)-α-methylhistamine at H3 receptors.

技术数据 for Immepip dihydrobromide

分子量 327.06
公式 C9H15N3.2HBr
储存 Desiccate at RT
CAS Number 164391-47-3
PubChem ID 22315065
InChI Key YGNJPNRDGXJQJX-UHFFFAOYSA-N
Smiles Br.Br.C(C1CCNCC1)C1=CNC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Immepip dihydrobromide

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 32.71 100

制备储备液 for Immepip dihydrobromide

以下数据基于产品分子量 327.06。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.06 mL 15.29 mL 30.58 mL
5 mM 0.61 mL 3.06 mL 6.12 mL
10 mM 0.31 mL 1.53 mL 3.06 mL
50 mM 0.06 mL 0.31 mL 0.61 mL

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产品说明书 for Immepip dihydrobromide

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for Immepip dihydrobromide

参考文献是支持产品生物活性的出版物。

Coruzzi et al (1995) Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat. Naunyn Schmiedebergs Arch.Pharmacol. 351 569 PMID: 7675114

Liu et al (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H4) expressed in bone marrow. Mol. Pharmacol. 59 420 PMID: 11179434

Vollinga et al (1994) A new potent and selective histamine H3 receptor agonist. J.Med.Chem. 37 332 PMID: 8308858

If you know of a relevant reference for Immepip dihydrobromide, please let us know.

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关键词: Immepip dihydrobromide, Immepip dihydrobromide supplier, H4, H3, agonists, Receptors, Histamine, histaminergic, 0932, Tocris Bioscience

1 篇 Immepip dihydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Immepip dihydrobromide 的部分引用包括：

Gründemann et al (2002) Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. Br J Pharmacol 137 910 PMID: 12411423

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Immepip dihydrobromide 的评论

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Study of H4 receptor in the DGR neurons.
By Anonymous on 12/24/2019
种属： Human

To test the potential role of H4 receptor in the DRG neurons, we first investigated the effects of H4 agonist immepip dihydrobromide (immepip) and histamine to in dissociated DRG neurons.

We applied 50 μM immepip and histamine to the dissociated DRG neurons in a chamber perfusion solution.

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