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Submit ReviewImmethridine dihydrobromide
Discontinued Product
2315 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Potent H3 agonist, highly selective over H4
化学名： 4-(1H-Imidazol-4-ylmethyl)pyridine dihydrobromide
纯度： ≥99% (HPLC)
生物活性 for Immethridine dihydrobromide
Immethridine dihydrobromide is a potent and highly selective histamine H3 receptor agonist (pEC50 = 9.74) that displays 300-fold selectivity over the H4 receptor (pKi values are 9.07 and 6.61 respectively). Does not bind to H1 or H2 receptors at concentrations up to 10 μM..
技术数据 for Immethridine dihydrobromide
| 分子量 | 321.01 |
| 公式 | C9H9N3.2HBr |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 699020-93-4 |
| PubChem ID | 16759172 |
| InChI Key | CYNKWHIKNDIVDR-UHFFFAOYSA-N |
| Smiles | Br.Br.C(C1=CN=CN1)C1=CC=NC=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Immethridine dihydrobromide
参考文献 for Immethridine dihydrobromide
参考文献是支持产品生物活性的出版物。
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
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关键词: Immethridine dihydrobromide, Immethridine dihydrobromide supplier, Potent, H3, agonists, selective, over, H4, Receptors, Histamine, histaminergic, 2315, Tocris Bioscience
Immethridine dihydrobromide 的评论
平均评分: 5 (Based on 1 Review.)
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H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide.
By
Anonymous on 12/24/2019
种属： Human
H3 receptor targetting study was conducted by various targeting molecules such as Immethridine dihydrobromide. How H3 receptor targeting may help in autoimmune was the aim for the study. Excellent product.Ideal results obtained.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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