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Submit ReviewImpentamine dihydrobromide
Discontinued Product
1858 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： Selective H3 antagonist
别名： VUF 4702
化学名： 4-(5-Aminopentyl)imidazole dihydrobromide
生物活性 for Impentamine dihydrobromide
Impentamine dihydrobromide is a potent and highly selective histamine H3 receptor antagonist (pA2 = 8.4); displays > 30000-fold selectivity over H1 and H2 receptors. Can act as a partial agonist in SK-N-MC cells expressing human H3 receptors. Produces antinociception, possibly via a non-H1, -H2 or -H3 receptor-mediated mechanism, following central administration in vivo.
技术数据 for Impentamine dihydrobromide
| 分子量 | 315.05 |
| 公式 | C8H15N3.2HBr |
| 储存 | Desiccate at RT |
| CAS Number | 149629-70-9 |
| PubChem ID | 53439849 |
| InChI Key | QSDXAAWBBPWGEL-UHFFFAOYSA-N |
| Smiles | Br.Br.NCCCCCC1=CN=CN1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Impentamine dihydrobromide
参考文献 for Impentamine dihydrobromide
参考文献是支持产品生物活性的出版物。
Hough et al (1999) Antinociceptive activity of impentamine, a histamine congener, after CNS administration. Life Sci. 64 PL79 PMID: 10072195
Vollinga et al (1995) Homologs of histamine as histamine H3 receptor antagonists: a new potent and selective H3 antagonist, 4(5)-(5-aminopentyl)-1H-imidazole. J.Med.Chem. 38 266 PMID: 7830269
Wieland et al (2001) Constitutive activity of histamine H3 receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H3 antagonists. J.Pharmacol.Exp.Ther. 299 908 PMID: 11714875
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关键词: Impentamine dihydrobromide, Impentamine dihydrobromide supplier, Selective, H3, antagonists, Receptors, Histamine, histaminergic, VUF4702, VUF, 4702, 1858, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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