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INCA-6

Cat. No. 2162 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Inhibitor of calcineurin-substrate association
化学名： 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
纯度： ≥95% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for INCA-6

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

技术数据 for INCA-6

分子量 284.31
公式 C20H12O2
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 3519-82-2
PubChem ID 230748
InChI Key GCHPUOHXXCNSQL-UHFFFAOYSA-N
Smiles O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for INCA-6

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 5.69 20

制备储备液 for INCA-6

以下数据基于产品分子量 284.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 17.59 mL 87.93 mL 175.86 mL
1 mM 3.52 mL 17.59 mL 35.17 mL
2 mM 1.76 mL 8.79 mL 17.59 mL
10 mM 0.35 mL 1.76 mL 3.52 mL

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参考文献 for INCA-6

参考文献是支持产品生物活性的出版物。

Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA 101 7554

If you know of a relevant reference for INCA-6, please let us know.

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关键词: INCA-6, INCA-6 supplier, inhibitors, inhibits, calcineurin, Protein, Ser/Thr, Phosphatases, NFAT, 2162, Tocris Bioscience

3 篇 INCA-6 的引用文献

引用文献是使用了 Tocris 产品的出版物。 INCA-6 的部分引用包括：

Bretz et al (2015) NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Exp Eye Res 5 14963 PMID: 26527057

Faralli et al (2015) NFATc1 activity regulates the expression of myocilin induced by dexameth. Nat Chem Biol 130 42614 PMID: 25450062

Savage et al (2015) RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS One 10 e0116941 PMID: 25617622

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