Iodophenpropit dihydrobromide

Cat. No. 0779 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent, selective H₃ antagonist

化学名： N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Iodophenpropit dihydrobromide

Iodophenpropit dihydrobromide is a selective H₃ antagonist with high affinity (K_D = 0.3 nM).

许可信息

Sold with the permission of SCI, Amsterdam

技术数据 for Iodophenpropit dihydrobromide

分子量	576.13
公式	C₁₅H₁₉IN₄S.2HBr
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	145196-87-8
PubChem ID	24978528
InChI Key	BOSOGNBLIWPCMS-UHFFFAOYSA-N
Smiles	Br.Br.IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Iodophenpropit dihydrobromide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	14.4	25

制备储备液 for Iodophenpropit dihydrobromide

以下数据基于产品分子量 576.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.25 mM	6.94 mL	34.71 mL	69.43 mL
1.25 mM	1.39 mL	6.94 mL	13.89 mL
2.5 mM	0.69 mL	3.47 mL	6.94 mL
12.5 mM	0.14 mL	0.69 mL	1.39 mL

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产品说明书 for Iodophenpropit dihydrobromide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Iodophenpropit dihydrobromide

参考文献是支持产品生物活性的出版物。

Jansen et al (1992) The first radiolabelled histamine H₃ receptor antagonist, [¹²⁵I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 217 203 PMID: 1330590

Jansen et al (1994) Characterisation of the binding of the first selective radiolabelled histamine H₃ receptor antagonist, [¹²⁵I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 113 355 PMID: 7834183

Menge et al (1992) Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[¹²⁵I]-iodophenylethyl]isothiourea sulfate [¹²⁵I]-iodophenpropit), a new probe for histamine H₃ receptor binding sites. J.Labelled Comp.Radiopharm. XXXI 10 781

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9

If you know of a relevant reference for Iodophenpropit dihydrobromide, please let us know.

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关键词: Iodophenpropit dihydrobromide, Iodophenpropit dihydrobromide supplier, Potent, selective, H3, antagonists, Receptors, Histamine, histaminergic, 0779, Tocris Bioscience

2 篇 Iodophenpropit dihydrobromide 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Iodophenpropit dihydrobromide 的部分引用包括：

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. BMC Neurosci 7 2336 PMID: 26114334

Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Toxins (Basel) 28 771 PMID: 24192459

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