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IQ 1S

Cat. No. 5575 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5575 has been discontinued.

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说明： JNK inhibitor; anti-inflammatory; also NO donor
化学名： 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
纯度： ≥99% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for IQ 1S

JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.

技术数据 for IQ 1S

分子量 269.23
公式 C15H8N3NaO
储存 Store at -20°C
纯度 ≥99% (HPLC)
CAS Number 1421610-21-0
PubChem ID 72193876
InChI Key JBNHEGDICQSOLR-NYAKATHWSA-M
Smiles [Na]O/N=C1C2=NC3=CC=CC=C3N=C2C4=C\1C=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for IQ 1S

参考文献是支持产品生物活性的出版物。

Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505 PMID: 25784649

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859

Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45 PMID: 26923672

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关键词: IQ 1S, IQ 1S supplier, IQ1S, JNK, inhibitors, inhibits, anti-inflammatory, immunosuppresents, NO, donor, JNK/c-jun, ROS, Donors, 5575, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for IQ 1S

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.