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说明： Selective JNK3 inhibitor
化学名： 11H-Indeno[1,2-b]quinoxalin-11-one O-(2-furanylcarbonyl)oxime
纯度： ≥98% (HPLC)
生物活性 for IQ 3
IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
技术数据 for IQ 3
| 分子量 | 341.32 |
| 公式 | C20H11N3O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 312538-03-7 |
| PubChem ID | 777728 |
| InChI Key | WBSWWONMTZEOGS-UHFFFAOYSA-N |
| Smiles | O=C(C5=CC=CO5)O/N=C3C2=NC1=CC=CC=C1N=C2C4=C/3C=CC=C4 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for IQ 3
参考文献 for IQ 3
参考文献是支持产品生物活性的出版物。
Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859
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关键词: IQ 3, IQ 3 supplier, IQ3, Selective, JNK, inhibitors, inhibits, JNK1, JNK2, JNK3, JNK/c-jun, c-jun, MAPK, kinases, 4550, Tocris Bioscience
1 篇 IQ 3 的引用文献
引用文献是使用了 Tocris 产品的出版物。 IQ 3 的部分引用包括：
Easton et al (2014) Genetic elimination of GABAergic neurotransmission reveals two distinct pacemakers for spontaneous waves of activity in the developing mouse cortex. J Neurosci 34 3854 PMID: 24623764
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
Pathways for IQ 3
