IRL-1620

Name: IRL-1620
Brand: Tocris Bioscience
SKU: 1196

Cat. No. 1196 8 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1196 has been discontinued.

View all ET<sub>B</sub> Receptors products.

说明： Highly selective ET_B agonist

纯度： ≥95% (HPLC)

说明书

引用文献 (8)

生物活性技术数据说明书参考文献

生物活性 for IRL-1620

IRL-1620 is a potent and highly selective ET_B endothelin receptor agonist (K_i values are 0.016 and 1900 nM at ET_B and ET_A receptors respectively). Discriminates two subpopulations of ET_B receptors. IRL-1620 prevents oxidative stress and cognitive impairment induced by Aβ in normal and diabetic rats; in a rat brain ischemia model it is neuroprotective, increases angiogenesis and neurogenesis, and promotes the recovery of neuronal function. Also promotes neural progenitor cell differentiation and maturation in vivo and in vitro.

技术数据 for IRL-1620

分子量	1820
公式	C₈₆H₁₁₇N₁₇O₂₇
序列	DEEAVYFAHLDIIW (Modifications: Asp-1 = Suc-Asp)
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	142569-99-1
PubChem ID	16130933
InChI Key	DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Smiles	CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CNC=N1)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CCC(O)=O)C(C)C)[C@@H](C)CC)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for IRL-1620

分析证书/产品说明书

化学品安全技术说明书

参考文献 for IRL-1620

参考文献是支持产品生物活性的出版物。

Haynes et al (1993) Endothelin; progress in pharmacology and physiology. TiPS 14 225 PMID: 8372400

Mazzoni et al (1999) Suc-[Glu⁹, Ala^11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET_B receptors in guinea-pig bronchus. Br.J.Pharmacol. 127 1406 PMID: 10455290

Sakamoto et al (1993) Distinct subdomains of human endothelin receptors determine their selectivity to endothelin_A-selective antagonist and endothelin_B-selective agonists. J.Biol.Chem. 268 8547 PMID: 8473300

Takai et al (1992) A potent and specific agonist, Suc-[Glu⁹,Ala^11,15]-endothelin-1(8-21), IRL 1620, for the ET_B receptor. Biochem.Biophys.Res.Commun. 184 953 PMID: 1315540

Ranjan et al (2020) Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke. Sci.Rep. 10 12737 PMID: 32728189

Briyal et al (2015) Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience 301 1 PMID: 26022359

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关键词: IRL-1620, IRL-1620 supplier, IRL1620, selective, ETB, agonists, Receptors, Endothelinb, alzheimers, Abeta, AB, Aβ, angiogenesis, neurogenesis, neuroprotective, Endothelin, Neural, Stem, Cells, 1196, Tocris Bioscience