iso-PPADS tetrasodium salt

Name: iso -PPADS tetrasodium salt
Brand: Tocris Bioscience
SKU: 0683
Rating: 5 (1 reviews)

Cat. No. 0683 5 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Non-selective P2X antagonist

化学名： Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt

说明书

引用文献 (5)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for iso-PPADS tetrasodium salt

iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pK_i = 6.5) with similar activity to PPADS.

2'4'-isomer also available.

技术数据 for iso-PPADS tetrasodium salt

分子量	599.3
公式	C₁₄H₁₀N₃Na₄O₁₂PS₂
储存	Desiccate at -20°C
CAS Number	207572-67-6
PubChem ID	5132514
InChI Key	LOTSPVPQHAUHCE-UHFFFAOYSA-N
Smiles	[Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for iso-PPADS tetrasodium salt

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	59.93	100

制备储备液 for iso-PPADS tetrasodium salt

以下数据基于产品分子量 599.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.67 mL	8.34 mL	16.69 mL
5 mM	0.33 mL	1.67 mL	3.34 mL
10 mM	0.17 mL	0.83 mL	1.67 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

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产品说明书 for iso-PPADS tetrasodium salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for iso-PPADS tetrasodium salt

参考文献是支持产品生物活性的出版物。

Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699

Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268

Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652

If you know of a relevant reference for iso-PPADS tetrasodium salt, please let us know.

按标靶查看相关产品

Purinergic (P2X) Receptors

关键词: iso-PPADS tetrasodium salt, iso-PPADS tetrasodium salt supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, 0683, Tocris Bioscience

5 篇 iso-PPADS tetrasodium salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 iso-PPADS tetrasodium salt 的部分引用包括：

Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887

Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216

Barría et al (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg 98 105 PMID: 29141748

Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723

Accorsi-Mendonça et al (2013) Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep 1 e00080 PMID: 24303152

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Good inhibitor.

By Anonymous on 06/06/2020

分析类型： In Vivo

种属： Mouse

细胞系/组织： phagocyte

H20 dilution 100 μM

该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

P2X and P2Y Receptors Scientific Review

Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.