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Submit ReviewIsoguvacine hydrochloride
说明： Selective GABAA agonist
化学名： 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
纯度： ≥99% (HPLC)
生物活性 for Isoguvacine hydrochloride
Isoguvacine hydrochloride is a specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
技术数据 for Isoguvacine hydrochloride
| 分子量 | 163.6 |
| 公式 | C6H9NO2.HCl |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 68547-97-7 |
| PubChem ID | 155107 |
| InChI Key | SUWREQRNTXCCBL-UHFFFAOYSA-N |
| Smiles | Cl.OC(=O)C=1CCNCC1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Isoguvacine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 100 |
制备储备液 for Isoguvacine hydrochloride
以下数据基于产品分子量 163.6。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.11 mL | 30.56 mL | 61.12 mL |
| 5 mM | 1.22 mL | 6.11 mL | 12.22 mL |
| 10 mM | 0.61 mL | 3.06 mL | 6.11 mL |
| 50 mM | 0.12 mL | 0.61 mL | 1.22 mL |
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产品说明书 for Isoguvacine hydrochloride
参考文献 for Isoguvacine hydrochloride
参考文献是支持产品生物活性的出版物。
Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980
Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717 PMID: 448364
Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113 PMID: 19535226
If you know of a relevant reference for Isoguvacine hydrochloride, please let us know.
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关键词: Isoguvacine hydrochloride, Isoguvacine hydrochloride supplier, Selective, GABAA, agonists, Receptors, 0235, Tocris Bioscience
5 篇 Isoguvacine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Isoguvacine hydrochloride 的部分引用包括：
Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol 104 403 PMID: 20445035
Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150
Sipilä et al (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29 6982 PMID: 19474325
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Br J Pharmacol 284 8726 PMID: 19141616
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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