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Submit ReviewIsotretinoin
说明： Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation
别名： 13-cis-retinoic acid,Accutane
化学名： 13-cis-Retinoic acid
纯度： ≥99% (HPLC)
生物活性 for Isotretinoin
Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.
技术数据 for Isotretinoin
| 分子量 | 300.44 |
| 公式 | C20H28O2 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 4759-48-2 |
| PubChem ID | 5282379 |
| InChI Key | SHGAZHPCJJPHSC-XFYACQKRSA-N |
| Smiles | C/C(/C=C/C=C(C)/C=C/C1=C(C)CCCC(C)1C)=C/C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Isotretinoin
参考文献 for Isotretinoin
参考文献是支持产品生物活性的出版物。
Diamandis et al (2007) Chemical genetics reveals a complex functional ground state of neural stem cells. Nat.Chem.Biol. 3 268 PMID: 17417631
Blaner et al (2001) Cellular metabolism and actions of 13-cis-retinoic acid. J.Am.Acad.Dermatol. 45 S129 PMID: 11606944
Sonawane et al (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br.J.Pharmacol. 171 5330 PMID: 25039756
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关键词: Isotretinoin, Isotretinoin supplier, Endogenous, agonists, retinoic, acid, receptors, neuronal, differentiation, anti-inflammatory, RAR, Retinoic, Acid, Receptors, RXR, Retinoid, X, 13-cis-retinoic, Accutane, Receptor, Neural, Stem, Cells, Retinal, 5513, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Isotretinoin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 篇 Isotretinoin 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Isotretinoin 的部分引用包括：
Cicero et al (2016) A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep 6 34798 PMID: 27739443
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.