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Submit ReviewISX 9
Discontinued Product
TB4439-RMU has been discontinued.
View all Ancillary Material Grade Small Molecules products.
说明： ISX 9 synthesized to Ancillary Material Grade
化学名： N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide
纯度： ≥98%
生物活性 for ISX 9
TB4439-RMU is an Ancillary Material Grade version of product ISX 9 (Cat. No. 4439). Suitable for use as an ancillary reagent in the further manufacturing of cell therapies.
Find out more about our Ancillary Material Grade product range.
技术数据 for ISX 9
| 分子量 | 234.27 |
| 公式 | C11H10N2O2S |
| 储存 | Store at 2-8°C |
| 纯度 | ≥98% |
| CAS Number | 832115-62-5 |
| InChI Key | SYENTKHGMVKGAQ-UHFFFAOYSA-N |
| Smiles | O=C(NC1CC1)C2=NOC(C3=CC=CS3)=C2 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for ISX 9
分析证书目前不在网上提供。
请联系客户服务
请联系客户服务
参考文献 for ISX 9
参考文献是支持产品生物活性的出版物。
Schneider et al (2008) Small-molecule activation of neuronal cell fate. Nat.Chem.Biol 4 408 PMID: 18552832
Dioum et al (2011) A small molecule differentiation inducer increases Ins production by pancreatic β cells. Proc.Natl.Acad.Sci.U.S.A. 108 20713 PMID: 22143803
Zhang et al (2011) Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression. Differentiation 81 233 PMID: 21419563
Russell et al (2012) Targeting native adult heart progenitors with cardiogenic small molecules. ACS Chem.Biol. 7 1067 PMID: 22413910
关键词: ISX 9, ISX 9 supplier, ISX9, ancillary, material, grade, isoxazoles, neurogenic, neuronal, differentiation, neuroD1, CaMKII, MEF2, neurogenesis, Isx1, Neuronal, differentiator, inducer, III, Ancillary, Material, Grade, Small, Molecules, TB4439-RMU, Tocris Bioscience
3 篇 ISX 9 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ISX 9 的部分引用包括：
Koh et al (2015) Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One 10 e0138724 PMID: 26407349
Pujol et al (2018) Isx9 Regulates Calbindin D28K Expression in Pancreatic β Cells and Promotes β Cell Survival and Function. Int J Mol Sci 19 PMID: 30150605
Xie et al (2018) β-actin regulates a heterochromatin landscape essential for optimal induction of neuronal programs during direct reprograming. PLoS Genet 14 e1007846 PMID: 30557298
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Stem Cell Research Product Guide
This product guide provides a background to the use of small molecules in stem cell research and lists over 200 products for use in:
- Self-renewal and Maintenance
- Differentiation
- Reprogramming
- Organoid Generation
- GMP and Ancillary Material Grade Products
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem Cell Workflow Poster
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.