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Submit ReviewJNJ 10181457 dihydrochloride
Discontinued Product
4019 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
说明： H3 antagonist
化学名： 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride
纯度： ≥98% (HPLC)
生物活性 for JNJ 10181457 dihydrochloride
Histamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.
许可信息
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
技术数据 for JNJ 10181457 dihydrochloride
| 分子量 | 385.37 |
| 公式 | C20H28N2O.2HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 544707-20-2 |
| PubChem ID | 10237424 |
| InChI Key | PAQHERKZFLOHCA-UHFFFAOYSA-N |
| Smiles | C1(CN2CCOCC2)=CC=CC(C#CCCN3CCCCC3)=C1.Cl.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for JNJ 10181457 dihydrochloride
参考文献 for JNJ 10181457 dihydrochloride
参考文献是支持产品生物活性的出版物。
Bonaventure et al (2007) Histamine H3 receptor antagonists: from target identification to drug leads. Biochem.Pharmacol. 73 1084 PMID: 17129577
Esbenshade et al (2008) The histamine H3 receptor: an attractive target for the treatment of cognitive disorders. Br.J.Pharmacol. 154 1166 PMID: 18469850
Boggs et al (2009) JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology 56 1131 PMID: 19345233
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关键词: JNJ 10181457 dihydrochloride, JNJ 10181457 dihydrochloride supplier, JNJ10181457, dihydrochloride, histamine, h3, receptors, antagonists, brain, penetrant, Histamine, H3, Receptors, 4019, Tocris Bioscience
1 篇 JNJ 10181457 dihydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 JNJ 10181457 dihydrochloride 的部分引用包括：
Iida (2017) JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice. Biochem Biophys Res Commun 488 534 PMID: 28526411
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