主页 / 药理学 / Ion Channels / Transient Receptor Potential Channels / TRPA1 / TRPA1 Activators / JT010

JT010

Cat. No. 6269 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective TRPA1 channel activator
化学名： 2-Chloro-N-[4-(4-methoxyphenyl)-2-thiazolyl]-N-(3-methoxypropyl)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JT010

JT010 is a potent and selective TRPA1 channel activator (EC50 = 0.65 nM); activates the TRPA1 channel by covalently and site-selectively binding to Cys621. Exhibits selectivity for TRPA1 over TRPV1, TRPV3, TRPV4, TRPM2, TRPM8, and TRPC5 channels (EC50 values are >1 μM).

技术数据 for JT010

分子量 354.85
公式 C16H19ClN2O3S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 917562-33-5
PubChem ID 18524489
InChI Key KZMAWJRXKGLWGS-UHFFFAOYSA-N
Smiles O=C(N(CCCOC)C1=NC(C2=CC=C(OC)C=C2)=CS1)CCl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JT010

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 35.48 100
ethanol 17.74 50

制备储备液 for JT010

以下数据基于产品分子量 354.85。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.09 mL 28.18 mL
5 mM 0.56 mL 2.82 mL 5.64 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

参考文献 for JT010

参考文献是支持产品生物活性的出版物。

Takaya et al (2015) A potent and site-selective agonist of TRPA1. J.Am.Chem.Soc. 137 15859 PMID: 26630251

If you know of a relevant reference for JT010, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 TRPA1 Activators

关键词: JT010, JT010 supplier, transient, receptor, potential, ankyrin, 1, selective, TRPA1, activators, activates, agonists, antagonism, potent, 6269, Tocris Bioscience

1 篇 JT010 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JT010 的部分引用包括：

Emmanouil et al (2022) Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression. Cell Rep Methods 2 100341 PMID: 36452863

您是否知道使用了 Tocris JT010 的优秀论文？ 请告知我们.

JT010 的评论

平均评分: 5 (Based on 1 Review.)

5 星
100%
4 星
0%
3 星
0%
2 星
0%
1 星
0%

Have you used JT010?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


An excellent TRPA1 channel activator.
By Zili Xie on 02/03/2019
分析类型： In Vivo
种属： Mouse
细胞系/组织： HEK293

300 nM JT010 evoked Calcium responses in HEK293 cells transfected with recombinant TRPA1.

review image