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JTV 519 fumarate

Cat. No. 4564 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Ryanodine receptor (RyR) inhibitor
别名： K 201
化学名： 1-(2,3-Dihydro-7-methoxy-1,4-benzothiazepin-4(5H)-yl)-3-[4-(phenylmethyl)-1-piperidinyl]-1-propanone fumarate
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JTV 519 fumarate

JTV 519 fumarate is a ryanodine receptor (RyR) inhibitor; stabilizes RyR2 in a closed conformation. Exhibits antiarrhythmic and cardioprotective properties in vivo.

技术数据 for JTV 519 fumarate

分子量 540.67
公式 C25H32N2O2S.C4H4O4
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1883549-36-7
PubChem ID 91826075
InChI Key ISLOBKLDZGDFTB-WLHGVMLRSA-N
Smiles O=C(CCN3CCC(CC4=CC=CC=C4)CC3)N2CCSC1=CC=C(OC)C=C1C2.O=C(/C=C/C(O)=O)O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JTV 519 fumarate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 54.07 100

制备储备液 for JTV 519 fumarate

以下数据基于产品分子量 540.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.25 mL 18.5 mL
5 mM 0.37 mL 1.85 mL 3.7 mL
10 mM 0.18 mL 0.92 mL 1.85 mL
50 mM 0.04 mL 0.18 mL 0.37 mL

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产品说明书 for JTV 519 fumarate

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for JTV 519 fumarate

参考文献是支持产品生物活性的出版物。

Hunt et al (2007) K201 (JTV519) suppresses spontaneous Ca2+ release and [3H]ryanodine binding to RyR2 irrespective of FKBP12.6 association. Biochem.J. 404 431 PMID: 17313373

Chen et al (2008) Effect of K201, a novel antiarrhythmic drug on calcium handling and arrhythmogenic activity of pulmonary vein cardiomyocytes. Br.J.Pharmacol. 153 915 PMID: 17994112

Ye et al (2012) Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1. Mol.Pharmacol. 81 53 PMID: 21989257

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关键词: JTV 519 fumarate, JTV 519 fumarate supplier, JTV519, fumarate, K201, ryanodine, receptors, inhibitors, inhibits, ryr1, ryr2, antiarrythmic, cardioprotective, K, 201, Ryanodine, Receptors, 4564, Tocris Bioscience

2 篇 JTV 519 fumarate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 JTV 519 fumarate 的部分引用包括：

Andreia S et al (2023) Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells. Cell Rep Methods 3 100456 PMID: 37159667

Chih-Cheng et al (2021) ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain. Elife 10 PMID: 34569932

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