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JW 480

Cat. No. 4327 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective inhibitor of serine hydrolase KIAA1363 (AADACL1)
化学名： 2-Isopropylphenyl(2-(naphthalen-2-yl)ethyl)carbamate
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for JW 480

JW 480 is a potent and selective inhibitor of the serine hydrolase enzyme KIAA1363 (neutral cholesterol ester hydrolase 1 or NCEH1) (IC50 = 20 nM in mouse brain). JW 480 impairs migration, invasion, survival and tumor growth of prostate cancer cell lines in vivo and reduces monoalkylglycerol ether (MAGE) levels.

许可信息

Sold under license from The Scripps Research Institute.

技术数据 for JW 480

分子量 333.42
公式 C22H23NO2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1354359-53-7
PubChem ID 57330099
InChI Key PCNJGBMWAZRVEA-UHFFFAOYSA-N
Smiles CC(C)C1=CC=CC=C1OC(NCCC2=CC=C(C=CC=C3)C3=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for JW 480

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 33.34 100
ethanol 33.34 100

制备储备液 for JW 480

以下数据基于产品分子量 333.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3 mL 15 mL 29.99 mL
5 mM 0.6 mL 3 mL 6 mL
10 mM 0.3 mL 1.5 mL 3 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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产品说明书 for JW 480

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for JW 480

参考文献是支持产品生物活性的出版物。

Chang et al (2011) A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem.Biol. 18 476 PMID: 21513884

If you know of a relevant reference for JW 480, please let us know.

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关键词: JW 480, JW 480 supplier, KIAA1363, inhibitors, inhibits, KIAA, 1363, prostate, cancer, AADACL1, MAGE, monoalkylglycerol, ether, JW480, neutral, cholesterol, ester, hydrolase, 1, NCEH1, Other, Hydrolases, 4327, Tocris Bioscience

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