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Submit ReviewK-(D-1-Nal)-FwLL-NH2
说明： High affinity and potent ghrelin receptor inverse agonist
生物活性 for K-(D-1-Nal)-FwLL-NH2
K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
技术数据 for K-(D-1-Nal)-FwLL-NH2
| 分子量 | 902.13 |
| 公式 | C51H67N9O6 |
| 序列 |
KXFWLL (Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide) |
| 储存 | Store at -20°C |
| CAS Number | 1394288-22-2 |
| PubChem ID | 71453489 |
| InChI Key | NCMQVOQOKBIHPA-MHRDGXECSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@H](CC1=CC=CC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for K-(D-1-Nal)-FwLL-NH2
参考文献 for K-(D-1-Nal)-FwLL-NH2
参考文献是支持产品生物活性的出版物。
Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID: 22920150
M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID: 26363071
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关键词: K-(D-1-Nal)-FwLL-NH2, K-(D-1-Nal)-FwLL-NH2 supplier, ghrelin, receptors, inverse, agonists, agonism, peptide, potent, high, affinity, Ghrelin, Receptors, 5830, Tocris Bioscience
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