K34c

Cat. No. 5114 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective α5β1 integrin inhibitor

化学名： N-(2,6-Dimethylbenzoyl)-O-[3-(2-pyridinylamino)propyl]-L-tyrosine

纯度： ≥98% (HPLC)

文献 (2)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for K34c

K34c is a potent and selective α5β1 integrin inhibitor (IC₅₀ = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide (Cat. No. 2706) or Ellipticine (Cat. No. 3357) and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltration in vivo and reduces cell adhesion on fibronectin.

技术数据 for K34c

分子量	447.53
公式	C₂₆H₂₉N₃O₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	939769-93-4
PubChem ID	16663328
InChI Key	VLNHAQFIBARCQP-UHFFFAOYSA-N
Smiles	O=C(C3=C(C)C=CC=C3C)N[C@H](C(O)=O)CC(C=C2)=CC=C2OCCCNC1=CC=CC=N1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for K34c

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	44.75	100
	ethanol	44.75	100

制备储备液 for K34c

以下数据基于产品分子量 447.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.17 mL	22.34 mL
5 mM	0.45 mL	2.23 mL	4.47 mL
10 mM	0.22 mL	1.12 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

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产品说明书 for K34c

分析证书/产品说明书

化学品安全技术说明书

参考文献 for K34c

参考文献是支持产品生物活性的出版物。

Heckmann et al (2007) Probing integrin selectivity: rational design of highly active and selective ligands for the α5β1 and αvβ3 integrin receptor. Angew.Chem.Int.Ed.Engl 46 3571 PMID: 17394271

Martinkova et al (2010) α5β1 integrin antagonists reduce chemotherapy-induced premature senescence and facilitate apoptosis in human glioblastoma cells. Int.J.Cancer 127 1240 PMID: 20099278

Renner et al (2016) Expression/activation of α5β1 integrin is linked to the β-catenin signaling pathway to drive migration in glioma cells. Oncotarget 7 62194 PMID: 27613837

Kuonen et al (2018) TGF-β, fibronectin and integrin α5β1 promote invasion in basal cell carcinoma. J.Invest.Dermatol. 138 2432 PMID: 29758283

If you know of a relevant reference for K34c, please let us know.

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关键词: K34c, K34c supplier, alpha5beta1, integrins, inhibitors, potent, selective, cell, adhesion, a5b1, alfa5beta1, Integrins, 5114, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.