Ketoconazole

Cat. No. 1103 4 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Cytochrome P450c17 inhibitor

化学名： cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl] methoxy]phenyl]piperazine

纯度： ≥99% (HPLC)

引用文献 (4)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Ketoconazole

Ketoconazole is an inhibitor of cytochrome P450c17. Enhances the formation of myelin basic protein-positive oligodendrocytes from oligodendrocyte progenitor cells in vitro and promotes remyelination in vivo. Also an antifungal agent. Brain penetrant.

技术数据 for Ketoconazole

分子量	531.44
公式	C₂₆H₂₈Cl₂N₄O₄
储存	Desiccate at +4°C
纯度	≥99% (HPLC)
CAS Number	65277-42-1
PubChem ID	456201
InChI Key	XMAYWYJOQHXEEK-OZXSUGGESA-N
Smiles	ClC1=CC(Cl)=[C@]([C@]3(OC[C@@](COC4=CC=C(N5CCN(C(C)=O)CC5)C=C4)([H])O3)CN2C=CN=C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ketoconazole

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	26.57	50
	DMSO	39.86	75

制备储备液 for Ketoconazole

以下数据基于产品分子量 531.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.75 mM	2.51 mL	12.54 mL	25.09 mL
3.75 mM	0.5 mL	2.51 mL	5.02 mL
7.5 mM	0.25 mL	1.25 mL	2.51 mL
37.5 mM	0.05 mL	0.25 mL	0.5 mL

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Reconstitution Calculator

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产品说明书 for Ketoconazole

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Ketoconazole

参考文献是支持产品生物活性的出版物。

Ayub and Levell (1989) Inhibition of human adrenal steroidogenic enzymes in vitro by imidazole drugs including ketoconazole. J.Steroid Biochem. 32 515 PMID: 2724954

Dumaine et al (1998) Blockade of HERG and Kv1.5 by ketoconazole. J.Pharmacol.Exp.Ther. 286 727 PMID: 9694927

Kuhn-Velten et al (1992) Ketoconazole inhibition of the bifunctional cytochrome P450c17 does not affect androgen formation from the endogenous lyase substrate. Biochem.Pharmacol. 44 2371 PMID: 1472102

Merck Index 12 5313

Hubler et al (2018) Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination. Nature 560 372 PMID: 30046109

Madhavan et al (2018) Induction of myelinating oligodendrocytes in human cortical spheroids. Nat.Methods. 15 700 PMID: 30046099

If you know of a relevant reference for Ketoconazole, please let us know.

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