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Submit ReviewKifunensine
说明： Inhibitor of class I α-mannosidases
化学名： (5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione
生物活性 for Kifunensine
Kifunensine is an inhibitor of class I α-mannosidases that inhibits glycoprotein processing. Kifunensine inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively. Kifunensine disrupts normal trafficking of the GLUT1 transporter, leading to decreased glucose uptake in human renal epithelial cells. Kifunensine impaires tumour cell aggregation in human ovarian cancer cells in vitro.
技术数据 for Kifunensine
| 分子量 | 232.19 |
| 公式 | C8H12N2O6 |
| 储存 | Store at -20°C |
| CAS Number | 109944-15-2 |
| PubChem ID | 130611 |
| InChI Key | OIURYJWYVIAOCW-PQMKYFCFSA-N |
| Smiles | O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)N2[C@@]([H])1NC(C2=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Kifunensine
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.16 | 5 超声处理 |
制备储备液 for Kifunensine
以下数据基于产品分子量 232.19。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.05 mM | 86.14 mL | 430.68 mL | 861.36 mL |
| 0.25 mM | 17.23 mL | 86.14 mL | 172.27 mL |
| 0.5 mM | 8.61 mL | 43.07 mL | 86.14 mL |
| 2.5 mM | 1.72 mL | 8.61 mL | 17.23 mL |
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产品说明书 for Kifunensine
参考文献 for Kifunensine
参考文献是支持产品生物活性的出版物。
Hering et al (2005) A practical synthesis of kifunensine analogues as inhibitors of endoplasmic reticulum α-Mannosidase I. J.Org.Chem. 70 9892 PMID: 16292820
Elbein et al (1990) Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I. J.Biol.Chem. 265 1559
Xiong et al (2018) Pharmacologic inhibition of N-linked glycan trimming with kifunensine disrupts GLUT1 trafficking and glucose uptake. Int.J.Mol.Sci. 19 890 PMID: 29562594
Hamester et al (2019) Prognostic relevance of the Golgi mannosidase MAN1A1 in ovarian cancer: impact of N-glycosylation on tumour cell aggregation. Br.J.Cancer 121 944 PMID: 31659304
If you know of a relevant reference for Kifunensine, please let us know.
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关键词: Kifunensine, Kifunensine supplier, inhibitors, inhibits, class, I, α-mannosidase, alpha-mannosidases, Glycosylases, Carbohydrate, Metabolism, 3207, Tocris Bioscience
1 篇 Kifunensine 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Kifunensine 的部分引用包括：
Elegheert et al (2018) Lentiviral transduction of mammalian cells for fast, scalable and high-level production of soluble and membrane proteins. Nat Protoc 13 2991 PMID: 30455477
您是否知道使用了 Tocris Kifunensine 的优秀论文？ 请告知我们.
Kifunensine 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Kifunensine?
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works as expected.
By
Anonymous on 10/23/2018
分析类型： In Vitro
种属： Human
细胞系/组织： HEK293
1 uM/mL culture for transient transfection in KEK293 cells
time added post transfect did not matter
