KJ Pyr 9

Cat. No. 5306 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： High affinity Myc inhibitor

化学名： 4-[2-(2-Furanyl)-6-(4-nitrophenyl)-4-pyridinyl]benzamide

纯度： ≥98% (HPLC)

引用文献 (2)

文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for KJ Pyr 9

KJ Pyr 9 is a high affinity Myc inhibitor (K_d = 6.5 nM). Disrupts Myc-Max interaction. Inhibits Myc-dependent cancer cell line proliferation in vitro. Inhibits growth of MDA-MB-231 breast cancer cell xenografts in mice. Brain penetrant.

技术数据 for KJ Pyr 9

分子量	385.37
公式	C₂₂H₁₅N₃O₄
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	581073-80-5
PubChem ID	85855478
InChI Key	GTTDVYCKFQYVNN-UHFFFAOYSA-N
Smiles	O=C(N)C(C=C1)=CC=C1C2=CC(C3=CC=CO3)=NC(C4=CC=C([N+]([O-])=O)C=C4)=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KJ Pyr 9

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	38.54	100

制备储备液 for KJ Pyr 9

以下数据基于产品分子量 385.37。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.97 mL	25.95 mL
5 mM	0.52 mL	2.59 mL	5.19 mL
10 mM	0.26 mL	1.3 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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产品说明书 for KJ Pyr 9

分析证书/产品说明书

化学品安全技术说明书

参考文献 for KJ Pyr 9

参考文献是支持产品生物活性的出版物。

Hart et al (2014) Inhibitor of MYC identified in a Kröhnke pyridine library. Proc.Natl.Acad.Sci.U.S.A. 111 12556 PMID: 25114221

If you know of a relevant reference for KJ Pyr 9, please let us know.

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关键词: KJ Pyr 9, KJ Pyr 9 supplier, KJPyr9, high, affinity, myc, inhibitors, inhibits, Myc-max, brain, penetrant, Myc, MYC, 5306, Tocris Bioscience

2 篇 KJ Pyr 9 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KJ Pyr 9 的部分引用包括：

Chau et al (2018) Downregulation of ribosome biogenesis during early forebrain development. Elife. e36998 PMID: 29745900

Ana et al (2020) Acute liver failure is regulated by MYC- and microbiome-dependent programs. Nat Med 26 1899-1911 PMID: 33106666

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.