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Submit ReviewKM 11060
说明： Corrects F508del-CFTR trafficking
化学名： 7-Chloro-4-[4-[4-chlorophenyl)sulfonyl]-1-piperazinyl]quinoline
纯度： ≥98% (HPLC)
生物活性 for KM 11060
KM 11060 is a corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
技术数据 for KM 11060
| 分子量 | 422.33 |
| 公式 | C19H17Cl2N3O2S |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 774549-97-2 |
| PubChem ID | 1241327 |
| InChI Key | GIEHIZKCIZLXLF-UHFFFAOYSA-N |
| Smiles | ClC(C=C4)=CC=C4S(N(CC3)CCN3C1=CC=NC2=C1C=CC(Cl)=C2)(=O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for KM 11060
参考文献 for KM 11060
参考文献是支持产品生物活性的出版物。
Robert et al (2008) Structural analog of silde. identified as a novel corrector of the F508del-CFTR trafficking defect. Mol.Pharmacol. 73 478 PMID: 17975008
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关键词: KM 11060, KM 11060 supplier, Corrects, F508del-CFTR, trafficking, Cl-, Channels, VSAC, Chloride, KM11060, pharmacochaperones, CFTR, 3143, Tocris Bioscience
1 篇 KM 11060 的引用文献
引用文献是使用了 Tocris 产品的出版物。 KM 11060 的部分引用包括：
Zhao et al (2013) Important role of platelets in modulating endotoxin-induced lung inflammation in CFTR-deficient mice. J Neuroinflammation 8 e82683 PMID: 24367540
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