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KRH 3955 hydrochloride

Cat. No. 6126 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

6126 has been discontinued.

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说明： Highly potent CXCR4 antagonist; inhibits HIV-1 replication
化学名： N1-[[4-[[(1H-Imidazol-2-ylmethyl)[(1-methyl-1H-imidazol-2-yl)methyl]amino]methyl]phenyl]methyl]-N1-methyl-N4,N4-dipropyl-1,4-butanediamine trihydrochloride
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for KRH 3955 hydrochloride

KRH 3955 hydrochloride is a highly potent CXCR4 antagonist (IC50 = 0.61 nM). Displays selectivity for CXCR4 over a range of other CXC receptors. Inhibits replication of HIV-1 viruses in human PBMC (EC50 values are 0.33 to 1.4 nM). Supresses HIV-1 infection in mice. Orally bioavailable.

技术数据 for KRH 3955 hydrochloride

分子量 589.09
公式 C28H45N7.3HCl
储存 Desiccate at RT
纯度 ≥98% (HPLC)
CAS Number 2253744-59-9
PubChem ID 137919856
InChI Key KLPOLRXJKIOFIQ-UHFFFAOYSA-N
Smiles CCCN(CCCCN(CC1=CC=C(C=C1)CN(CC2=NC=CN2C)CC3=NC=CN3)C)CCC.Cl.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for KRH 3955 hydrochloride

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参考文献 for KRH 3955 hydrochloride

参考文献是支持产品生物活性的出版物。

Murakami et al (2009) The novel CXCR4 antagonist KRH-3955 is an orally bioavailable and extremely potent inhibitor of human immunodeficiency virus type 1 infection: comparative studies with AMD3100. Antimicrob.Agents Chemother. 53 2940 PMID: 19451305

Iwasaki et al (2009) Efficient inhibition of SDF-1α-mediated chemotaxis and HIV-1 infection by novel CXCR4 antagonists. Cancer Sci. 100 778 PMID: 19245436

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