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KS 176

Cat. No. 4169 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective BCRP inhibitor
化学名： N-[4-(2-Hydroxyethyl)phenyl]-2-[(4-nitrobenzoyl)amino]benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KS 176

KS 176 is a selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter (IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively). Displays no inhibitory activity against P-gp or MRP1.

技术数据 for KS 176

分子量 405.4
公式 C22H19N3O5
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1253452-78-6
PubChem ID 49779726
InChI Key LTWQQWSXYYXVGA-UHFFFAOYSA-N
Smiles OCCC1=CC=C(NC(C2=C(NC(C3=CC=C([N+]([O-])=O)C=C3)=O)C=CC=C2)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KS 176

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 40.54 100

制备储备液 for KS 176

以下数据基于产品分子量 405.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.47 mL 12.33 mL 24.67 mL
5 mM 0.49 mL 2.47 mL 4.93 mL
10 mM 0.25 mL 1.23 mL 2.47 mL
50 mM 0.05 mL 0.25 mL 0.49 mL

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参考文献 for KS 176

参考文献是支持产品生物活性的出版物。

Pick et al (2010) Specific inhibitors of the breast cancer resistance protein (BCRP). ChemMedChem 5 1498 PMID: 20632361

If you know of a relevant reference for KS 176, please let us know.

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关键词: KS 176, KS 176 supplier, KS176, selective, inhibitors, inhibits, breast, cancer, resistance, protein, BCRP, multidrug, transporter, ATP-binding, cassettes, Multidrug, Transporters, 4169, Tocris Bioscience

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