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KT 182

Cat. No. 6738 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor
化学名： [4-[3'-(Hydroxymethyl)[1,1'-biphenyl]-4-yl]-1H-1,2,3-triazol-1-yl](2-phenyl-1-piperidinyl)methanone
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for KT 182

KT 182 is a potent, selective and irreversible α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 1.7 nM). KT 182 exhibits selectively for ABHD6 over other brain and liver serine hydrolases, but does exhibit some activity at carboxylesterase-1. KT 182 inhibits ABHD6 activity in the brain and liver in mice following intraperitoneal administration.

技术数据 for KT 182

分子量 438.53
公式 C27H26N4O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1402612-62-7
PubChem ID 53364491
InChI Key GICNKPZHUCVFNM-UHFFFAOYSA-N
Smiles OCC1=CC=CC(C2=CC=C(C3=CN(C(N4CCCCC4C5=CC=CC=C5)=O)N=N3)C=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for KT 182

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 43.85 100

制备储备液 for KT 182

以下数据基于产品分子量 438.53。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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参考文献 for KT 182

参考文献是支持产品生物活性的出版物。

Hsu et al (2013) Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6) J.Med.Chem. 56 8270 PMID: 24152295

If you know of a relevant reference for KT 182, please let us know.

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关键词: KT 182, KT 182 supplier, KT182, potent, selective, irreversible, alpha/beta-hydrolase, α/β, alfa, domains, 6, ABHD6, inhibitors, inhibits, Other, Hydrolases, 6738, Tocris Bioscience

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