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KU14R

Cat. No. 1131 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1131 has been discontinued.

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说明： Antagonist of pancreatic imidazoline receptor
化学名： 2-(2-Ethyl-2,3-dihydro-2-benzofuranyl)-1H-imidazole
纯度： ≥99% (HPLC)
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for KU14R

KU14R is a antagonist of the atypical imidazoline binding site (putative I3 receptor) of pancreatic β-cells. Selectively blocks efaroxan-induced insulin secretion in vitro and in vivo.

技术数据 for KU14R

分子量 214.27
公式 C13H14N2O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 189224-48-4
PubChem ID 4302964
InChI Key JCWVNNMJXQJVNC-UHFFFAOYSA-N
Smiles CCC1(CC2=CC=CC=C2O1)C1=NC=CN1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for KU14R

参考文献是支持产品生物活性的出版物。

Chan et al (1997) The putative endogenous imidazoline receptor ligand, clonidine-displacing substance, is a potent Ins secretagogue in rat and human islets of Langerhans. Br.J.Pharmacol. 120 926 PMID: 9138700

Chan et al (1997) Clotrimazole and efaroxan stimulate Ins secretion by different mechanisms in rat pancreatic islets. Naunyn Schmiedebergs Arch.Pharmacol. 356 763 PMID: 9453462

Mayer and Taberner (2002) Effects of the imidazoline ligands efaroxan and KU14R on blood glucose in the mouse. Eur.J.Pharmacol. 454 95 PMID: 12409010

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关键词: KU14R, KU14R supplier, Antagonists, pancreatic, imidazoline, receptors, I3, Receptors, 1131, Tocris Bioscience

1 篇 KU14R 的引用文献

引用文献是使用了 Tocris 产品的出版物。 KU14R 的部分引用包括：

Mourtada et al (1999) Multiple effector pathways regulate the Ins secretory response to the imidazoline RX871024 in isolated rat pancreatic islets. Br J Pharmacol 127 1279 PMID: 10455276

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