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L-651,582

Cat. No. 3086 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Non-selective Ca2+ channel blocker
别名： Carboxyamidotriazole
化学名： 5-Amino-1-[[3,5-dichloro-4-(4-chlorobenzoyl)phenyl]methyl]-1H-1,2,3-triazole-4-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for L-651,582

L-651,582 is an orally active Ca2+ channel blocker; inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Exhibits antiproliferative, antiangiogenic and antimetastatic activity in vivo and displays selectivity towards numerous mismatch repair-deficient tumor cell lines in vitro.

技术数据 for L-651,582

分子量 424.67
公式 C17H12Cl3N5O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 99519-84-3
PubChem ID 108144
InChI Key WNRZHQBJSXRYJK-UHFFFAOYSA-N
Smiles ClC1=CC=C(C(C2=C(Cl)C=C(CN3N=NC(C(N)=O)=C3N)C=C2Cl)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-651,582

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.47 100

制备储备液 for L-651,582

以下数据基于产品分子量 424.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.77 mL 23.55 mL
5 mM 0.47 mL 2.35 mL 4.71 mL
10 mM 0.24 mL 1.18 mL 2.35 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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产品说明书 for L-651,582

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for L-651,582

参考文献是支持产品生物活性的出版物。

Hupe et al (1991) The inhibition of receptor-mediated and voltage-dependent calcium entry by the antiproliferative L-651,582 J.Biol.Chem. 266 10136 PMID: 1645340

Yang et al (2008) Selective sensitivity to carboxyamidotriazole by human tumor cell lines with DNA mismatch repair deficiency. Int.J.Cancer. 123 258 PMID: 18464258

Felder et al (1991) The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release. J.Pharm.Exp.Ther. 257 967

If you know of a relevant reference for L-651,582, please let us know.

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关键词: L-651,582, L-651,582 supplier, Ca2+, channel, blockers, Calcium, CaV, Channels, voltage-gated, voltage-dependent, L651582, Carboxyamidotriazole, Non-selective, Cav, 3086, Tocris Bioscience

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