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Submit ReviewL-655,240
说明： Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist
化学名： 1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
纯度： ≥99% (HPLC)
生物活性 for L-655,240
Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo.
技术数据 for L-655,240
| 分子量 | 373.85 |
| 公式 | C21H21ClFNO2 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 103253-15-2 |
| PubChem ID | 122070 |
| InChI Key | JLPYLHLUHJOPNL-UHFFFAOYSA-N |
| Smiles | CC1=C(CC(C)(C)C(O)=O)N(CC2=CC=C(Cl)C=C2)C2=CC=C(F)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-655,240
参考文献 for L-655,240
参考文献是支持产品生物活性的出版物。
Hall et al (1987) Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist. Eur.J.Pharmacol. 135 193 PMID: 3582493
Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361
Wainright and Parratt (1988) The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J.Cardiovasc.Pharmacol. 12 264 PMID: 2464097
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关键词: L-655,240, L-655,240 supplier, Potent, selective, thromboxane, A2, endoperoxide, TP, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L655240, Receptors, 1698, Tocris Bioscience
1 篇 L-655,240 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-655,240 的部分引用包括：
Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033
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