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Submit ReviewL-AP6
说明： Selective agonist of the 'quis' effect
化学名： L-(+)-2-Amino-6-phosphonohexanoic acid
生物活性 for L-AP6
L-AP6 is a selective agonist for 'quis'-sensitized site.
技术数据 for L-AP6
| 分子量 | 211.15 |
| 公式 | C6H14NO5P |
| 储存 | Store at RT |
| CAS Number | 78944-89-5 |
| PubChem ID | 3062646 |
| InChI Key | QIOXWRQXHFVNLV-YFKPBYRVSA-N |
| Smiles | [H][C@@](CCCCP(O)(O)=O)(N)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-AP6
参考文献 for L-AP6
参考文献是支持产品生物活性的出版物。
Johansen et al (1995) Type 4a metabotropic glutamate receptor: identification of new potent agonists and differentiation from the L-(+)-2-amino-4-phosphonobutanoic acid-sensitive receptor in the lateral perforant pathway in rats. Mol.Pharmacol. 48 140 PMID: 7623768
Schulte et al (1994) Utilization of the resolved L-isomer of 2-amino-6-phosphonohexanoic acid (L-AP6) as a selective agonist for a quisqualate-sensitized site in hippocampal CA1 pyramidal neurons. Brain Res. 649 203 PMID: 7953634
Venkatraman et al (1994) Synthesis of oxadiazolidinedione derivatives as quisqualic acid analogues and their evaluation at a quisqualate-sensitized site in the rat hippocampus. J.Med.Chem. 37 3939 PMID: 7966155
关键词: L-AP6, L-AP6 supplier, Selective, agonists, quis, effect, Glutamate, mGlur, Receptors, Metabotropic, iGluR, Ionotropic, Miscellaneous, 0341, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.