L-Buthionine sulfoximine

Cat. No. 6954 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis

化学名： (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid

纯度： ≥98% (HPLC)

引用文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for L-Buthionine sulfoximine

L-Buthionine sulfoximine is an irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.

技术数据 for L-Buthionine sulfoximine

分子量	222.3
公式	C₈H₁₈N₂O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	83730-53-4
PubChem ID	119565
InChI Key	KJQFBVYMGADDTQ-CVSPRKDYSA-N
Smiles	CCCC[S](=N)(=O)CC[C@H](N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-Buthionine sulfoximine

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	22.23	100
	DMSO	22.23	100

制备储备液 for L-Buthionine sulfoximine

以下数据基于产品分子量 222.3。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	4.5 mL	22.49 mL	44.98 mL
5 mM	0.9 mL	4.5 mL	9 mL
10 mM	0.45 mL	2.25 mL	4.5 mL
50 mM	0.09 mL	0.45 mL	0.9 mL

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产品说明书 for L-Buthionine sulfoximine

分析证书/产品说明书

化学品安全技术说明书

参考文献 for L-Buthionine sulfoximine

参考文献是支持产品生物活性的出版物。

Griffith & Meister (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J.Biol.Chem. 254 7558 PMID: 38242

Griffith et al (1982) Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem. 257 13704 PMID: 6128339

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385

If you know of a relevant reference for L-Buthionine sulfoximine, please let us know.

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1 篇 L-Buthionine sulfoximine 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-Buthionine sulfoximine 的部分引用包括：

Gregory H et al (2021) Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep 37 110037 PMID: 34818536

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