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Submit ReviewL-CCG-l
说明： Potent group II mGlu agonist
别名： (2S,3S,4S)-CCG
化学名： (2S,1'S,2'S)-2-(Carboxycyclopropyl)glycine
纯度： ≥99% (HPLC)
生物活性 for L-CCG-l
L-CCG-l is a potent group II metabotropic glutamate receptor agonist. More active than glutamate or (±)-trans-ACPD (Cat. No. 0187).
技术数据 for L-CCG-l
| 分子量 | 159.14 |
| 公式 | C6H9NO4 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 117857-93-9 |
| PubChem ID | 5310956 |
| InChI Key | GZOVEPYOCJWRFC-HZLVTQRSSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@]1([C@@](O)=O)[H] |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-CCG-l
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 100 |
制备储备液 for L-CCG-l
以下数据基于产品分子量 159.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.28 mL | 31.42 mL | 62.84 mL |
| 5 mM | 1.26 mL | 6.28 mL | 12.57 mL |
| 10 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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产品说明书 for L-CCG-l
参考文献 for L-CCG-l
参考文献是支持产品生物活性的出版物。
Brabet et al (1998) Comparative effect of L-CCG-I, DCG-IV and γ-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes. Neuropharmacology 37 1043 PMID: 9833633
Hayashi et al (1992) Agonist analysis of 2-(carboxycyclopropyl)glycine isomers for cloned metabotropic glutamate receptor subtypes expressed in Chinese hamster ovary cells. Br.J.Pharmacol. 107 539 PMID: 1330184
Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213 PMID: 2692753
Wright and Schoepp (1996) Differentiation of group 2 and group 3 metabotropic glutamate receptor cAMP responses in the rat hippocampus. Eur.J.Pharmacol. 297 275 PMID: 8666060
If you know of a relevant reference for L-CCG-l, please let us know.
关键词: L-CCG-l, L-CCG-l supplier, Potent, group, II, mGlur, agonists, Group, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, (2S,3S,4S)-CCG, (Metabotropic), 0333, Tocris Bioscience
4 篇 L-CCG-l 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-CCG-l 的部分引用包括：
Han et al (2015) Alleviation of kainic acid-induced brain barrier dysfunction by 4-o-methylhonokiol in in vitro and in vivo models. Biomed Res Int 2015 893163 PMID: 25688368
Scholler (2017) HTS-compatible FRET-based conformational sensors clarify membrane receptor activation. Nat Chem Biol 13 372 PMID: 28135236
Caiati et al (2012) Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. Sci Rep 2 285 PMID: 22368777
Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. Neuron 108 9993 PMID: 21628565
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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