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说明： Potent, competitive glutamate uptake inhibitor
别名： (2S,3S,4R)-CCG
化学名： (2S,1'S,2'R)-2-(Carboxycyclopropyl)glycine
生物活性 for L-CCG-lll
Potent and competitive inhibitor of both glial and neuronal uptake of glutamate, aspartate and cysteate.
技术数据 for L-CCG-lll
| 分子量 | 159.14 |
| 公式 | C6H9NO4 |
| 储存 | Store at RT |
| CAS Number | 117857-95-1 |
| PubChem ID | 5310957 |
| InChI Key | GZOVEPYOCJWRFC-NUNKFHFFSA-N |
| Smiles | N[C@]([H])(C(O)=O)[C@@]([H])(C1)[C@@]([H])1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-CCG-lll
分析证书目前不在网上提供。
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参考文献 for L-CCG-lll
参考文献是支持产品生物活性的出版物。
Kawai et al (1992) 2-Carboxycyclopropyl)glycine: binding, neurotoxicity and induction of intracellular free Ca2+ increase. Eur.J.Pharmacol. 211 195 PMID: 1319341
Nakamura et al (1993) (2S,3S,4R)-2-(Carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789
Shinozaki et al (1989) Potent NMDA-like actions and potentiation of glutamate responses by conformational variants of a glutamate analogue in the rat spinal cord. Br.J.Pharmacol. 98 1213 PMID: 2692753
Yamashita et al (1995) Inhibition by folded isomers of L-2-(carboxycyclopropyl)glycine of glutamate uptake via the human glutamate transporter hGluT-I. Eur.J.Pharmacol. 289 387 PMID: 7621914
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关键词: L-CCG-lll, L-CCG-lll supplier, Potent, competitive, reuptake, inhibitors, inhibits, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, (2S,3S,4R)-CCG, 0332, Tocris Bioscience
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.