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说明： Glutaminase inhibitor; also inhibits other glutamine-using enzymes and transporters
化学名： 6-Diazo-5-oxo-L-norleucine
生物活性 for L-DON
L-DON is a glutaminase inhibitor (Ki = 6 μM). Also inhibits other glutamine-using enzymes, amino acid transporters and transglutaminases. Displays antitumor effects and reduces tumor weight in a range of mouse xenograft models.
技术数据 for L-DON
| 分子量 | 171.15 |
| 公式 | C6H9N3O3 |
| 储存 | Store at -20°C |
| CAS Number | 157-03-9 |
| PubChem ID | 9087 |
| InChI Key | YCWQAMGASJSUIP-YFKPBYRVSA-N |
| Smiles | N[C@H](C(O)=O)CCC(C=[N+]=[N-])=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for L-DON
参考文献 for L-DON
参考文献是支持产品生物活性的出版物。
Thomas et al (2013) Kinetic characterization of ebselen, chelerythrine and apomor. as glutaminase inhibitors. Biochem.Biophys.Res.Commun. 438 243 PMID: 23850693
Ovejera et al (1979) Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-γ-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice. Cancer Res. 39 3220 PMID: 572261
Lemberg et al (2018) We're not "DON" yet: optimal dosing and prodrug delivery of 6-diazo-5-oxo-L-norleucine. Mol.Cancer Ther. 17 1824 PMID: 30181331
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关键词: L-DON, L-DON supplier, DON, norleucine, glutaminase, inhibitors, inhibits, Glutaminase, 6809, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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