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Submit ReviewL-Glutamic acid
说明： Endogenous, non-selective glutamate receptor agonist
化学名： (S)-1-Aminopropane-1,3-dicarboxylic acid
生物活性 for L-Glutamic acid
L-Glutamic acid is a the predominant excitatory transmitter in the mammalian central nervous system. L-Glutamic acid acts at ionotropic and metabotropic glutamate receptors.
MNI-caged-L-glutamate (Cat. No. 1490) also available.
技术数据 for L-Glutamic acid
| 分子量 | 147.13 |
| 公式 | C5H9NO4 |
| 储存 | Store at RT |
| CAS Number | 56-86-0 |
| PubChem ID | 33032 |
| InChI Key | WHUUTDBJXJRKMK-VKHMYHEASA-N |
| Smiles | [H][C@@](CCC(O)=O)(N)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-Glutamic acid
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| 1eq. NaOH | 100 |
制备储备液 for L-Glutamic acid
以下数据基于产品分子量 147.13。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.8 mL | 33.98 mL | 67.97 mL |
| 5 mM | 1.36 mL | 6.8 mL | 13.59 mL |
| 10 mM | 0.68 mL | 3.4 mL | 6.8 mL |
| 50 mM | 0.14 mL | 0.68 mL | 1.36 mL |
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产品说明书 for L-Glutamic acid
参考文献 for L-Glutamic acid
参考文献是支持产品生物活性的出版物。
Monaghan et al (1989) The excitatory amino acid receptors: their classes, pharmacology and distinct properties in the function of the central nervous system. Annu.Rev.Pharmacol.Toxicol. 29 365 PMID: 2543272
Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
Yang and Stockwell et al (2016) Ferroptosis: Death by lipid peroxidation. Trends Cell Biol. 26 165 PMID: 26653790
If you know of a relevant reference for L-Glutamic acid, please let us know.
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关键词: L-Glutamic acid, L-Glutamic acid supplier, Endogenous, non-selective, agonists, Glutamate, Ionotropic, Non-Selective, iGluR, Receptors, mGlur, Metabotropic, Non-selective, mGlu, Ferroptosis, Amino, Acids, 0218, Tocris Bioscience
9 篇 L-Glutamic acid 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-Glutamic acid 的部分引用包括：
Kopach et al (2022) Multi-target action of beta -alanine protects cerebellar tissue from ischemic damage. Cell Death Dis 13 747 PMID: 36038575
Calò et al (2005) Interactions between ephrin-B and metabotropic glutamate 1 receptors in brain tissue and cultured neurons. J Neurosci 25 2245 PMID: 15745950
Schitine et al (2015) Functional plasticity of GAT-3 in avian Müller cells is regulated by neurons via a glutamatergic input. J Neurosci 82 42 PMID: 25700791
Galici et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther 318 173 PMID: 16608916
Owaisat et al (2012) In vivo comparison of harmine efficacy against psychostimulants: preferential inhibition of the cocaine response through a glutamatergic mechanism. Neurosci Lett 525 12 PMID: 22877698
Tallarida et al (2012) Glutamate carboxypeptidase II (GCPII) inhibitor displays anti-glutamate and anti-cocaine effects in an invertebrate assay. Amino Acids 42 2521 PMID: 21850438
Moreno et al (2012) Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem 287 44301 PMID: 23129762
Falcucci et al (2019) Novel positive allosteric modulators of glutamate transport have neuroprotective properties in an in vitro excitotoxic model. ACS Chem Neurosci 10 3437 PMID: 31257852
Moreno et al (2011) Maternal influenza viral infection causes schizophrenia-like alterations of 5-HT2A and mGlu2 receptors in the adult offspring. J Neurosci 31 1863 PMID: 21289196
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L-Glutamic acid 的评论
平均评分: 4.7 (基于 3 条评论。)
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Action of felbamate and beta-alanine on NMDA receptors.
By
Anonymous on 06/21/2023
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： Cerebellum
Glutamic acid (10 mM) + glycine (10 mM) were used to activate NMDA receptors in outside-out membrane patch and then test action of beta-alanine and felbamate on glycine binding site. As expected, activation of NMDARs was fully legible.
Neuron glia culture.
By
Anonymous on 07/12/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Mixed neuron-glia
L-glutamate (10 or 100μM)
Incubate for 24h
works good.
By
Anonymous on 04/04/2020
分析类型： In Vitro
种属： Rat
细胞系/组织： Sprague-Dawley rats primary neuronal
10 μM L-Glutamic acid for 2 hours
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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