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L-(-)-threo-3-Hydroxyaspartic acid

Cat. No. 0183 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
别名： L-threo-β-Hydroxyaspartic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for L-(-)-threo-3-Hydroxyaspartic acid

L-(-)-threo-3-Hydroxyaspartic acid is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 11, 19, and 14 μM, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values are 3.6, 3.8 and 3.2 μM for human EAAT1, EAAT2 and EAAT3, respectively.

技术数据 for L-(-)-threo-3-Hydroxyaspartic acid

分子量 149.1
公式 C4H7NO5
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 7298-99-9
PubChem ID 443239
InChI Key YYLQUHNPNCGKJQ-LWMBPPNESA-N
Smiles [H][C@@]([C@]([H])(O)C(O)=O)(N)C(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for L-(-)-threo-3-Hydroxyaspartic acid

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
1eq. NaOH 100

制备储备液 for L-(-)-threo-3-Hydroxyaspartic acid

以下数据基于产品分子量 149.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 6.71 mL 33.53 mL 67.07 mL
5 mM 1.34 mL 6.71 mL 13.41 mL
10 mM 0.67 mL 3.35 mL 6.71 mL
50 mM 0.13 mL 0.67 mL 1.34 mL

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产品说明书 for L-(-)-threo-3-Hydroxyaspartic acid

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for L-(-)-threo-3-Hydroxyaspartic acid

参考文献是支持产品生物活性的出版物。

Johnston et al (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurones by the stereoisomers of threo-3-hydroxyaspartate. J.Neurochem. 34 241 PMID: 7452241

McBean and Roberts (1985) Neurotoxicity of L-glutamate and DL-threo-3-hydroxyaspartate in the rat striatum. J.Neurochem. 44 247 PMID: 2856883

Nakamura et al (1993) (2S,3S,4R)-2-(carboxycyclopropyl)glycine, a potent and competitive inhibitor of both glial and neuronal uptake of glutamate. Neuropharmacology 32 833 PMID: 7901789

Jensen and Bräuner-Osborne (2004) Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem.Pharmacol. 67 2115 PMID: 15135308

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关键词: L-(-)-threo-3-Hydroxyaspartic acid, L-(-)-threo-3-Hydroxyaspartic acid supplier, potent, competitive, Transportable, EAAT1, EAAT2, EAAT3, EAAT4, EAAT1-4, inhibitors, inhibits, non-transportable, EAAT5, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, L-threo-beta-Hydroxyaspartic, acid, L-threo-b-Hydroxyaspartic, 0183, Tocris Bioscience

1 篇 L-(-)-threo-3-Hydroxyaspartic acid 的引用文献

引用文献是使用了 Tocris 产品的出版物。 L-(-)-threo-3-Hydroxyaspartic acid 的部分引用包括：

Nakade et al (2018) Gut microbiota-derived D-serine protects against acute kidney injury. JCI Insight 3 PMID: 30333299

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该领域的文献

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Huntington's Disease Poster

Huntington's Disease Poster

Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.