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Submit ReviewL-trans-2,4-PDC
说明： Transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor
别名： trans-4-Carboxy-L-proline
化学名： L-trans-Pyrrolidine-2,4-dicarboxylic acid
纯度： ≥97% (HPLC)
生物活性 for L-trans-2,4-PDC
L-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. In [3H]-d-Asp uptake assays in HEK293 cells expressing human EAAT1, EAAT2 and EAAT3, Ki values are 20, 20 and 109 μM, respectively. In a FLIPR Membrane Potential (FMP) assay, Km values for L-trans-2,4-PDC are 7.7, 11 and 19 μM for human EAAT2, EAAT3 and EAAT1, respectively.
技术数据 for L-trans-2,4-PDC
| 分子量 | 159.14 |
| 公式 | C6H9NO4 |
| 储存 | Store at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 64769-66-0 |
| PubChem ID | 1515192 |
| InChI Key | NRSBQSJHFYZIPH-DMTCNVIQSA-N |
| Smiles | O=[C@]([C@H]1NC[C@H]([C@@](O)=O)C1)O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for L-trans-2,4-PDC
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 15.91 | 100 |
制备储备液 for L-trans-2,4-PDC
以下数据基于产品分子量 159.14。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.28 mL | 31.42 mL | 62.84 mL |
| 5 mM | 1.26 mL | 6.28 mL | 12.57 mL |
| 10 mM | 0.63 mL | 3.14 mL | 6.28 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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产品说明书 for L-trans-2,4-PDC
参考文献 for L-trans-2,4-PDC
参考文献是支持产品生物活性的出版物。
Bridges et al (1991) Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer. J.Med.Chem. 34 717 PMID: 1671706
Mitrovic and Johnston (1994) Regional differences in the inhibition of L-glutamate amd L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylic threo-3-hydroxy-D-aspartate and D-aspartate. Neurochem.Int. 24 583 PMID: 7981641
Zuiderwijk et al (1996) Effects of uptake carrier blockers SK & F 89976-A and L-trans-PDC on in vivo release of amino acids in rat hippocampus. Eur.J.Pharmacol. 307 275 PMID: 8836615
Jensen and Bräuner-Osborne (2004) Pharmacological characterization of human excitatory amino acid transporters EAAT1, EAAT2 and EAAT3 in a fluorescence-based membrane potential assay. Biochem.Pharmacol. 67 2115 PMID: 15135308
If you know of a relevant reference for L-trans-2,4-PDC, please let us know.
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关键词: L-trans-2,4-PDC, L-trans-2,4-PDC supplier, potent, competitive, Transportable, EAAT1-4, EAAT2, EAAT3, EAAT4, inhibitors, inhibits, non-transportable, EAAT5, EAAT, Excitatory, Amino, Acid, Transporters, GLAST, GLT-1, Glutamate, Monoamine, Neurotransmitter, reuptake, trans-4-Carboxy-L-proline, Acids, 0298, Tocris Bioscience
4 篇 L-trans-2,4-PDC 的引用文献
引用文献是使用了 Tocris 产品的出版物。 L-trans-2,4-PDC 的部分引用包括：
Yin and Weiss (2012) Marked synergism between mutant SOD1 and glutamate transport inhibition in the induction of motor neuronal degeneration in spinal cord slice cultures. Brain Res 1448 153 PMID: 22370146
Heinrich et al (2012) K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. Br J Pharmacol 167 1003 PMID: 22394324
Beaulé et al (2009) Circadian modulation of gene expression, but not glutamate uptake, in mouse and rat cortical astrocytes. PLoS One 4 e7476 PMID: 19829696
Young et al (2007) Glutamate receptor expression and chronic glutamate toxicity in rat motor cortex. PLoS One 26 78 PMID: 17240155
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.