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Submit ReviewLamotrigine isethionate
说明： Inhibits glutamate release. Water-soluble salt of lamotrigine (Cat. No. 1611)
化学名： 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine isethionate
纯度： ≥99% (HPLC)
生物活性 for Lamotrigine isethionate
Lamotrigine isethionate is a water-soluble salt of lamotrigine (Cat. No. 1611). Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for Lamotrigine isethionate
| 分子量 | 382.22 |
| 公式 | C9H7Cl2N5.C2H6O4S |
| 储存 | Desiccate at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 113170-86-8 |
| PubChem ID | 45039646 |
| InChI Key | CJIDZLNMKONKAD-UHFFFAOYSA-N |
| Smiles | OCCS(O)(=O)=O.NC1=NC(N)=C(N=N1)C1=CC=CC(Cl)=C1Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Lamotrigine isethionate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 38.22 | 100 温和加热 |
制备储备液 for Lamotrigine isethionate
以下数据基于产品分子量 382.22。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.62 mL | 13.08 mL | 26.16 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
| 10 mM | 0.26 mL | 1.31 mL | 2.62 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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产品说明书 for Lamotrigine isethionate
参考文献 for Lamotrigine isethionate
参考文献是支持产品生物活性的出版物。
Leach et al (1991) Neurochemical and behavioral aspects of lamotr. Epilepsia 32 S4 PMID: 1685439
Smith and Meldrum (1995) Cardioprotective effect of lamotr. after focal ischemia in rats. Stroke 26 117 PMID: 7839380
Zona and Avoli (1997) Lamotrigine reduces voltage-gated sodium currents in rat central neurons in culture. Epilepsia 38 522 PMID: 9184596
Grunze et al (1998) Modulation of calcium and potassium currents by lamotr. Neuropsychobiology 38 131 PMID: 9778600
If you know of a relevant reference for Lamotrigine isethionate, please let us know.
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关键词: Lamotrigine isethionate, Lamotrigine isethionate supplier, inhibitors, inhibits, glutamate, release, Receptors, GlaxoSmithKline, GSK, Miscellaneous, Glutamate, Other, Channel, Modulators, 2289, Tocris Bioscience
1 篇 Lamotrigine isethionate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Lamotrigine isethionate 的部分引用包括：
Madry et al (2018) Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron 97 299 PMID: 29290552
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