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LCL 161, phenol

Cat. No. 7178 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Functionalized IAP ligand for PROTACs
化学名： tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
纯度： ≥95% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for LCL 161, phenol

LCL 161, phenol is a functionalized IAP (XIAP and cIAP) ligand for PROTAC® research and development. Boc protected LCL 161. Supplied with a phenol functional handle for ready conjugation to a linker/target protein ligand. NanoBRET assays show EC50 values of 7.5, 18.2 and 25.3 nM for cIAP1, XIAP and cIAP2 proteins, respectively. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines for LCL 161, phenol

This product is provided for use in onward chemistry. Suitable solvents can be used.

技术数据 for LCL 161, phenol

分子量 598.76
公式 C31H42N4O6S
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 2095244-42-9
InChI Key SPXBMEKMIPOEMC-LQGLAIQGSA-N
Smiles OC1=CC(C(C2=CSC([C@@H]3CCCN3C([C@H](C4CCCCC4)NC([C@@H](N(C(OC(C)(C)C)=O)C)C)=O)=O)=N2)=O)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for LCL 161, phenol

分析证书/产品说明书
化学品安全技术说明书

参考文献 for LCL 161, phenol

参考文献是支持产品生物活性的出版物。

Ohoka et al (2017) In vivo knockdown of pathogenic proteins via specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs). J.Biol.Chem. 292 4556 PMID: 28154167

Shimokawa et al (2017) Targeting the allosteric site of oncoprotein BCR-ABL as an alternative strategy for effective target protein degradation. ACS Med.Chem.Lett. 8 1042 PMID: 29057048

Schwalm et al (2022) A toolbox for the generation of chemical probes for baculovirus IAP repeat containing proteins. Front.Cell.Dev.Biol. 10 886537 PMID: 35721509

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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia